تمرینات تناوبی با شدت بالا همراه با مکمل زعفران، نشانگرهای استرس-التهابی را در زنان چاق مبتلا به دیابت نوع 2 تعدیل می‌کند.

نوع مقاله : مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I

نویسندگان

1 دانشجوی دکتری فیزیولوژی پزشکی، گروه فیزیولوژی پزشکی، دانشکده پزشکی، دانشگاه کانکوک، سئول، کره جنوبی.

2 کارشناسی ارشد فیزیولوژی ورزشی، گروه فیزیولوژی ورزشی، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه گیلان، رشت، ایران.

3 دانشجوی دکتری فیزیولوژی ورزشی، گروه فیزیولوزی ورزشی، دانشکده علوم انسانی و اجتماعی، دانشگاه کردستان، سنندج، ایران

10.34785/J019.2022.002

چکیده

مقدمه: هدف از این مطالعه بررسی اثرات تعاملی مکمل عصاره زعفران به همراه تمرین تناوبی با شدت بالا (HIIT) بر سطوح سرمی نشانگرهای استرس-التهابی در زنان چاق مبتلا به دیابت نوع 2 بود.
روش: سی و دو زن چاق مبتلا به دیابت نوع 2 به طور تصادفی به 4 گروه مداخله: مکمل، تمرین تناوبی با شدت بالا + مکمل، دارونما و دارونما + HIIT تقسیم شدند. ویژگی‌های آنتروپومتریک و خونی آزمودنی‌ها در پیش‌آزمون و پس‌آزمون ارزیابی شد. روش مکمل‌دهی به این صورت بود که گروه مکمل روزانه 100 میلی‌گرم عصاره زعفران دریافت می‌کردند. آزمودنی‌های گروه تمرین نیز در 4 نوبت با شدت 85 تا 95 درصد حداکثر ضربان قلب به همراه 4 دوره استراحت فعال با شدت 50 تا 60 درصد حداکثر ضربان قلب روی تردمیل می‌دویدند.
نتایج: تجزیه و تحلیل داده‌ها نشان داد که اثر زمان، کاهش معنی‌داری در سطوح سرمی IL-6، NT-proBNP و GDF-15 در گروه‌های مکمل، مکمل+HIIT و دارونما+HIIT بود (0.05≤P). نتایج تعامل زمان × گروه نیز تفاوت معنی‌داری را بین گروه‌ها نشان داد (0.05≤P). به طوری که کاهش سطوح نشانگرهای استرس-التهابی در گروه مکمل+HIIT کاهش بیشتری داشت.
نتیجه‌گیری: با توجه به نتایج، می‌توان گزارش کرد که HIIT و مکمل زعفران (ترکیبی از هر دو) احتمالاً با کاهش توده چربی، سطوح نشانگرهای استرس-التهابی مانند GDF-15، NT-proBNP و IL-6 را کاهش می‌دهند و همچنین متابولیسم گلوکز و مقاومت به انسولین را در زنان چاق مبتلا به دیابت بهبود می‌بخشند.

تازه های تحقیق

 

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

High-intensity interval training combined with saffron supplementation modulates stress-inflammatory markers in obese women with type 2 diabetes

نویسندگان [English]

  • Shadi Golpasasndi 1
  • Siamand Abdollahpour 2
  • Hadi Golpasandi 3
1 PhD student of medical physiology, Department of Medical Physiology, Faculty of Medicine, Kankuk University, Seoul, South Korea.
2 Master of exercise physiology, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Guilan, Rasht, Guilan, Iran.
3 Ph.D of exercise physiology, Department of Exercise physiology, Faculty of Humanities and Social Sciences, University of Kurdistan, Sanandaj, Iran.
چکیده [English]

Introduction: The aim of this study was to investigate the interactive effects of saffron extract supplementation with high-intensity interval training (HIIT) on serum levels of stress-inflammatory markers in obese women with type 2 diabetes.

Method: Thirty-two obese women with type 2 diabetes were randomly divided into 4 intervention groups: supplement, HIIT +Supplement, placebo and placebo+ HIIT. The anthropometric and blood characteristics of subjects were evaluated in pre-test and post-test. The method of supplementation was that the supplement group received 100 mg of saffron extract daily. The subjects in the training group also did running on the treadmill in 4 bouts with intensity of 85 to 95% of the maximum heart rate along with 4 periods of active rest at the intensity of 50 to 60% of the maximum heart rate.

Results: Data analysis showed that the effect of time was a significant decrease in serum levels of IL-6, NT-proBNP, and GDF-15 in the supplement, supplement+ HIIT and placebo+ HIIT groups (P≤0.05). The results of time × group interaction also showed a significant difference between the groups (P≤0.05). So that the decrease in the levels of stress-inflammatory markers in the supplement+ HIIT group had a greater decrease.

Conclusion: According to the results, it can be reported that HIIT and saffron supplementation (combination of both) probably reduces the levels of stress-inflammatory markers such as GDF-15, NT-proBNP, and IL-6 by reducing fat mass, as well as also improve glucose metabolism and insulin resistance in obese women with diabetes.

کلیدواژه‌ها [English]

  • Growth differentiation factor-15
  • interleukin-6
  • NT-proBNP
  • inflammation
  • type 2 diabetes

 

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