تأثیر مکمل بتا-هیدروکسی-β-متیل بوتیرات بر IL-4، IL-10 و TGF-β1 در طول ورزش مقاومتی در ورزشکاران

رحیمی, محمد رحمان; شکر نژاد, حمید

doi:10.34785/J019.2022.524

تأثیر مکمل بتا-هیدروکسی-β-متیل بوتیرات بر IL-4، IL-10 و TGF-β1 در طول ورزش مقاومتی در ورزشکاران

نوع مقاله : مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I

نویسندگان

¹ دانشیار فیزیولوژی ورزشی، گروه فیزیولوژی ورزشی، دانشکده علوم انسانی و اجتماعی، دانشگاه کردستان، سنندج، کردستان، ایران.

² کارشناسی ارشد فیزیولوژی ورزشی، گروه فیزیولوژی ورزشی، دانشکده علوم انسانی و اجتماعی، دانشگاه کردستان، سنندج، کردستان، ایران.

10.34785/J019.2022.524

چکیده

هدف از این مطالعه بررسی تأثیر مکمل بتا-هیدروکسی-β-متیل بوتیرات (HMB) بر سیتوکین‌های ضد التهابی شامل IL-4، IL-10 و TGF-β در طول یک جلسه تمرین مقاومتی حاد (RE) در مردان جوان تمرین کرده با تمرینات مقاومتی بود. ده مرد تمرین کرده با تمرینات مقاومتی در یک مطالعه تصادفی، دوسوکور، کنترل شده با دارونما و متقاطع، به مدت 7 روز مکمل HMB (3×1 گرم در روز HMB) و دارونما (3×1 گرم در روز مالتودکسترین) با یک دوره استراحت 7 روزه دریافت کردند. پس از دوره‌های مکمل، آزمودنی‌ها سه ست پرس سینه، کشش لت به پایین، جلو پا، پشت پا، جلو بازو، جلو بازو، جلو بازو، جلو بازو و پرس شانه تا حد ناتوانی با 85٪ از یک تکرار بیشینه (1RM) انجام دادند. نمونه‌های خون قبل (قبل)، بلافاصله پس از (IP) و 1 ساعت پس از RE (1 ساعت P) برای ارزیابی غلظت سرمی IL-4، IL-10 و TGF-β1 گرفته شد. داده‌ها با استفاده از تحلیل واریانس با اندازه‌گیری‌های مکرر (ANOVA) 2 (تیمار: HMB و PL) × 3 (نقاط زمانی: قبل، قبل و بعد از 1 ساعت تمرین) و به دنبال آن آزمون تعقیبی بونفرونی با سطح معنی‌داری p<0.05 تجزیه و تحلیل شدند. IL-4 سرم در تمرین مقاومتی IP در HMB در مقایسه با دارونما به طور معنی‌داری بالاتر بود. IL-4 و TGF-β1 در گردش خون در IP در مقایسه با قبل در هر دو گروه HMB و دارونما به طور معنی‌داری افزایش یافت. هیچ تفاوت معنی‌داری بین تیمارها برای IL-10 و TGF-β1 در هیچ یک از نقاط زمانی مشاهده نشد. در نتیجه، مکمل HMB سطح IL-4 در گردش خون را در طول RE در مردان تمرین کرده با مقاومت افزایش داد، که ممکن است التهاب را کاهش داده و سازگاری با RE را تسهیل کند.

تازه های تحقیق

کلیدواژه‌ها

عنوان مقاله [English]

Effects of β-Hydroxy-β-Methylbutyrate Supplementation on IL-4, IL-10 and TGF-β1 during Resistance Exercise in Athletes

نویسندگان [English]

Mohammad Rahman Rahimi ¹
Hamid Shoker-Nejad ²

¹ Associate Professor of Exercise Physiology, Department of Exercise Physiology, Faculty of Humanities and Social Sciences, University of Kurdistan, Sanandaj, Kurdistan, Iran.

² Master of exercise physiology, Department of Exercise Physiology, Faculty of Humanities and Social Sciences, University of Kurdistan, Sanandaj, Kurdistan, Iran.

چکیده [English]

The aim of this study was to investigate the effect of β-Hydroxy-β-methylbutyrate (HMB) supplementation on anti-inflammatory cytokines including IL-4, IL-10 and TGF-β during an acute bout of resistance exercise (RE) in young resistance trained men. Ten resistance-trained men in a randomized, double-blind, placebo-controlled and crossover study, were administered a 7-day HMB supplementation (3×1 g.d-1 of HMB) and placebo (3×1 g.d-1 of Maltodextrin) with a 7 days washout period. After supplementation periods, subjects performed three sets of bench press, lat pull down, leg extension, leg curl, biceps curl, triceps curl and shoulder press to failure with 85% of one repetition to maximum (1RM). Blood samples were obtained before- (Pre), immediately post- (IP) and 1 hour-post RE (1h P) to assess serum concentrations of IL-4, IL-10 and TGF-β1. The data were analyzed using 2 (treatment: HMB and PL) × 3 (time points: Pre, IP and 1hP) repeated measures analysis of variance (ANOVA) followed by the Bonferroni post hoc test with a significant level of p<0.05. Serum IL-4 was significantly higher at IP resistance exercise in HMB compared to placebo. Circulating IL-4 and TGF-β1 were significantly raised at IP compared to Pre in both HMB and placebo treatments. No significant differences between treatments were observed for IL-10 and TGF-β1at any time points. In conclusion, HMB supplementation increased the circulating level of IL-4 during RE in resistance-trained men, which may attenuate inflammation and facilitate adaptation to RE.

کلیدواژه‌ها [English]

β-Hydroxy-β-Methylbutyrate
anti-inflamatory cytokines
resistance exercise

اصل مقاله

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