The effect of exercise with an energy expenditure of 3000 kcal per week on hsCRP, MDA, and insulin resistance in overweight women

Document Type : Research Paper I Open Access I Released under (CC BY-NC 4.0) license

Authors

1 Department of Exercise Physiology, Faculty of Physical Education and Sport Science, University of Tabriz, Tabriz, Iran.

2 Department of Sport Sciences, Faculty of Educational Sciences and Psychology, Azerbaijan Shahid Madani University , Tabriz, Iran.

3 Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tabriz, Tabriz, Iran.

Abstract

Given the prevalence of overweight and the associated increase in oxidative stress as one of its major adverse consequences, the present study aimed to the effects of exercise with an energy expenditure of 3000 kcal per week on hsCRP, MDA, and insulin resistance in overweight women.

This experimental study followed a pre-–post-test design and was conducted on 27 participants divided into three groups high-energy expenditure exercise (HCE), standard-energy expenditure exercise (SCE), and control (CON). The training program for the HCE group involved an energy expenditure of 1200 kcal (50–60% VO2max) in the first week and 3000 kcal (70–85% VO2max) in the final week. The SCE group with an energy expenditure of 900 kcal (65–75% VO2max) in the first week and 1200 kcal (70–85% VO2max) in the final week. MDA, hsCRP, insulin, and HOMA-IR were measured as indicators of oxidative stress, inflammation, and insulin resistance. Data analyzed using a 2×3 repeated-measures ANOVA at a significance level of P≤0.05. the findings, a significant reduction in MDA levels was observed only in the SCE group across measurement phases (P=0.043).,a significant increase in hsCRP was found in the HCE group compared to the SCE (P=0.010) and CON (P=0.005) groups. No other significant differences were observed (P>0.05).

Based on the results, combined training with an energy expenditure of 3000 kcal per week, compared to standard exercise protocols, did not result in significant increases in oxidative stress, systemic inflammation, or insulin dysfunction after 12 weeks., such high-energy training protocols can be considered metabolically and inflammatorily safe.

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History

  • Receive Date: 24 June 2025
  • Revise Date: 23 July 2025
  • Accept Date: 26 July 2025
  • First Publish Date: 26 July 2025

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