The Effect of Aerobic Training Along with Water-Soluble Q10 Supplementation on nigrostriatal necroptosis related Genes’ Expression and plasma Q10 level in Rat Model of Parkinson's Disease

Document Type : Research Paper I Open Access I Released under (CC BY-NC 4.0) license

Authors

1 Department of Physical Education and Sport Sciences, Faculty of Humanities, Islamic Azad University, Tabriz Branch, Tabriz, Iran.

2 Department of Physical Education & Sport Sciences, Faculty of Humanities, Tabriz Branch, Islamic Azad University, Tabriz, Iran,

10.22034/ren.2025.143692.1106

Abstract

Aim: The aim of this study was to investigate effect of aerobic training along with water-soluble q10 supplementation on nigrostriatal necroptosis related genes’ expression and plasma Q10 level in rat model of Parkinson's disease

Method: Forty male Wistar rats were randomly assigned into five groups: Sham (healthy control), PD, PD-aerobic training, PD-Q10, and PD-combined intervention. PD was induced by intracerebral injection of 6-OHDA, and confirmed through apomorphine testing. The aerobic training regimen consisted of four weeks of treadmill running (five days/week), including two sessions (duration= 15 min) each day with 60 min rest interval at running speed of 15 meters/minute. 200 mg/kg body weight of water-soluble Q10 or saline (as vehicle) was administered orally each day. Motor coordination was assessed using Rotarod test, tissue BDNF expression level was measured using ELISA and the number of contact neurons in substantia nigra and also proportion of TH+ neurons count in respect to sham group were respectively determined by histology and immunohistology methods. Data were compared using ANOVA and paired samples t-tests.

Results: Significant between group differences were observed in plasma Q10, gene expression levels of RIPK1, MLKL and TNFR as well as muscle rigidity (P=0.001 in all circumstances).

Conclusion: Altogether, the available evidences are in favor of the higher efficacy of the combined intervention for exercising PD models which still warrants to be more explored.

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Research in Exercise Nutrition
Volume 3, Issue 4
Completing and uploading accepted articles
January 2024

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History

  • Receive Date: 28 May 2025
  • Revise Date: 12 June 2025
  • Accept Date: 26 June 2025
  • First Publish Date: 26 June 2025

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