Influence of Aerobic Training along with Arginine Supplementation on Hunger Rate, Meal Satiety Quotient and Plasma Gene Expression Level of miR-200a-3p and miR-103a-3p in Obese women

Document Type : Research Paper I Open Access I Released under (CC BY-NC 4.0) license

Authors

1 Department of Sport Sciences, Faculty of Education and Psychology, Azarbaijan Sahid Madani University, Tabriz, Iran.

2 Department of Sport Sciences, Faculty of Education and Psychology, Azarbaijan Shahid Madani University, Tabriz, Iran.

Abstract

The aim was to investigate the impact of eight weeks of aerobic training with and without arginine supplementation on hunger, meal satiety, and the expression of miR-200a-3p and miR-103a-3p genes in plasma of obese women
48 inactive volunteer women (age 57.41 ± 4.69 years and body mass index 34.09 ± 1.09 kg/m²) were randomized into aerobic exercise and placebo, aerobic exercise and arginine supplementation, or arginine supplementation and placebo (without exercise) groups. They participated in an eight-week aerobic exercise program, consisting of treadmill running with a GTX test at 60% of the heart rate at exhaustion, completing 500 calories (three days a week). They also consumed arginine at a dose of 0.07 grams per kilogram of body weight daily. One-way analysis of variance and paired t-test were used to analyze the data.
Results: The expression of both miR-200a-3p and miR-103a-3p genes was significantly reduced in all three groups (P<0.05). In the arginine supplementation group, there was no significant reduction in waist circumference, body weight, and time to exhaustion (P>0.05). In the aerobic exercise plus arginine supplementation group, all indices, including gene expression, waist circumference, body weight, hunger, meal satiety, and time to exhaustion, were significantly improved (P<0.05). Additionally, in the aerobic exercise group, there was no significant decrease in hunger and meal satiety (P>0.05).
Conclusion: Aerobic exercise and arginine supplementation reduce the expression of miR-200a-3p and miR-103a-3p genes as well as hunger sensation. Additionally, they improve obesity indices (waist circumference and body weight), immediate satiety quotient, and time to exhaustion.

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Research in Exercise Nutrition
Volume 3, Issue 4
January 2024

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History

  • Receive Date: 14 May 2025
  • Revise Date: 04 June 2025
  • Accept Date: 08 June 2025
  • First Publish Date: 08 June 2025

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