نوع مقاله : مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I
نویسندگان
1 گروه تربیت بدنی و علوم ورزشی، دانشکده علوم انسانی، دانشگاه آزاد اسلامی واحد تبریز، تبریز، ایران.
2 گروه تربیت بدنی و علوم ورزشی، دانشکده علوم انسانی، واحد تبریز، دانشگاه آزاد اسلامی، تبریز، ایران.
چکیده
کلیدواژه‌ها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Aim: The aim of this study was to investigate effect of aerobic training along with water-soluble q10 supplementation on nigrostriatal necroptosis related genes’ expression and plasma Q10 level in rat model of Parkinson's disease
Method: Forty male Wistar rats were randomly assigned into five groups: Sham (healthy control), PD, PD-aerobic training, PD-Q10, and PD-combined intervention. PD was induced by intracerebral injection of 6-OHDA, and confirmed through apomorphine testing. The aerobic training regimen consisted of four weeks of treadmill running (five days/week), including two sessions (duration= 15 min) each day with 60 min rest interval at running speed of 15 meters/minute. 200 mg/kg body weight of water-soluble Q10 or saline (as vehicle) was administered orally each day. Motor coordination was assessed using Rotarod test, tissue BDNF expression level was measured using ELISA and the number of contact neurons in substantia nigra and also proportion of TH+ neurons count in respect to sham group were respectively determined by histology and immunohistology methods. Data were compared using ANOVA and paired samples t-tests.
Results: Significant between group differences were observed in plasma Q10, gene expression levels of RIPK1, MLKL and TNFR as well as muscle rigidity (P=0.001 in all circumstances).
Conclusion: Altogether, the available evidences are in favor of the higher efficacy of the combined intervention for exercising PD models which still warrants to be more explored.
کلیدواژه‌ها [English]
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